Cystic fibrosis (CF) is a genetic disease caused by a defect in a gene called CFTR in particular (cystic fibrosis transmembrane conductance regulator). About 1 in 25 European ancestry have this gene. However, the possibility of CF is more like 1 in 3,000, because you only if both parents have the gene. This should be about 1 in 625 (25 * 25) the ability, but because of genetic mixing is reduced to about 1 in 3,000 for people of European descent. People with otherracial origin have the gene for cystic fibrosis, less frequently, and then CF is less common in other ethnic groups.
There are several types of cystic fibrosis, such as various genetic defects. This means that the best medication varies for different people with CF. Diet and exercise advice is uniform, however, and depends more on people's food preferences and fitness.
What are the symptoms of cystic fibrosis?
Change the ability of CFEpithelial cells of the lung, liver, pancreas, intestine, genital organs and the skin for the transport of chloride ions. In practice this means that distinguishes the concentration of chloride ions inside and outside the cell from the normal situation. Many of these epithelial cells produce mucus and chloride concentration leads to an abnormal mucus from the cells less sticky and more moist. This leads to problems in the lungs and pancreas. Within the skin, sweat glands produce moreChloride than normal, and that is the basis for a test to detect CF.
Lung problems:
Normally, this can be a sticky mucus obstruction of small airways in the lungs, causing difficulty in breathing. Even microbes that are made to them are not able to be efficiently removed. The mucus of the respiratory tract usually is deflected as the treadmill slows down, because it is viscous. This means that microbes are more likely to settle in the lungs and moredifficult to remove. A chronic inflammatory reaction is established, which over time leads to the formation of scar tissue (fibrosis) and the occurrence of cysts. Hence the name "cystic fibrosis" state. Lung problems are usually caused by the inhalation of substances that expand the bronchial tubes, such as steroids, addressed the cause. The substances that cause inflammation, like ibuprofen to reduce, may also be used.
Because people with CF bacteria in the lungs, which are harmful to others, haveCystic fibrosis is usually not recommended that too much time with other people with the condition. In the past, the inhalers between people with CF and that was particularly damaging to split their chances in life.
Digestive problems:
The pancreas is an organ, pancreatic juice that you digest your food, that the intake of nutrients can help produce. CF pancreatic juice contains enzymes, fats, carbohydrates and proteins can be achievedblocked by sticky mucus. This is especially a problem for the digestion of fats, such as carbohydrates (eg bread, pasta and sweets) can be broken in the mouth, and proteins (such as chicken, tuna and soya) in the stomach. A small amount of fat can be broken down in the mouth and stomach by lingual lipase and gastric lipase enzymes, respectively. However, these enzymes are generally not sufficient to reduce fat is good enough for efficient absorption. As a result, people with CF have become in a shortessential fatty acids and fat-soluble vitamins A, D, E and K are Nowadays, most people with CF digestive enzymes, to obtain sufficient amounts of these nutrients if you eat a good diet if allowed.
The operation of the Gene:
To understand why a genetic disease like cystic fibrosis occurs, it is necessary to understand a little bit "of genetics.
As you are born, you are 23 chromosomes from the mother and 23 from the father given. They are redundant, since eachThe 23 pairs of chromosomes with the chromosome corresponds to a different parent. At a certain point on the chromosome is a gene. Normally it takes to create more than one gene to a sudden, like hair color or the amount of oxygen in the blood can carry. However, there are cases in which a single gene creates a distance.
The widow's peak hairline is a single gene trait. Even if only one parent brings you end up with a receding hairline on both sides, because the widow's peak characteristic of a dominantGene. You will only end with a smooth hair, if both parents carry the recessive gene (non-dominant).
Cystic fibrosis is another single-gene trait. If mother and father have the gene, then there is a good chance that you will understand it. If a parent get the gene it is not because other parents CF gene can be used. It's a bit more complex than this, as the sperm meets egg in, your father your mother mix their DNA in a way that a CF gene can change in non-CFGene and thus the chances of a CF is reduced.
The CFTR gene, like most genes makes proteins that the body can use. The normal CFTR gene produces a protein that transports chloride ions into and out of epithelial cells. may be affected in the transport of other ions. Several errors (or mutations, as they are known in genetics) can affect the CFTR gene. The most common (called ?F508) causes a protein to create does not bend properly. It's hard to get these misfoldedProteins in the cell membrane, so that it can escape to chloride ions.
It is a good exercise for people with cystic fibrosis?
Definitely yes. Exercise, both cardiovascular and strength training help to many of the symptoms manifested by the FC improve.
It clears the airways in the lungs. This brings more oxygen to the growth of certain bacteria that their camp in the lungs of people with CF can be can be slow.
Increases lungCapacity, making it easier to breathe.
Increases strength and endurance. CF does not reduce the ability to exercise direct, but the infection of the lung and deficiency can affect strength and endurance. Exercises and cardiovascular exercises that are to participate to share the burden with your body weight or movable weights all. Exercise generally increases the appetite, which should contribute to nutritional deficiencies.
Increases bone density. This is because in the absence of importantVitamins D and K can develop people with CF to weaker bones.
A person with CF should be aware that they have more salt during the exercise, sweat, and for this reason it may be necessary to use a sports drink with plenty of salt. Not all sports drinks contain salt. A list of those who are not in order of decreasing salt content: (* PowerbarEndurance; High5 Isotonic *; ISOSTAR * Taut; High5EnergySource; LucozadeSport; InfinitRide *;Powerade). Well, not the dust, ISOSTAR may be the best. Remember, colas contain very little salt.
Remember that this with a '*' to them in the form of dust. For purposes of comparison that will probably up to an isotonic force to be watered. About 60grams of powder per liter of water. Are in bold in the rule in stores form.If liquid you avoid artificial sweeteners (Lucozade) and excess calcium found(ISOSTAR), then the High5 Powerbar and powders are a good choice. Alternatively, add 1 / 2 grams of salt for a 500 ml bottle with a typical drink fruit juice.
What is the best diet for people with cystic fibrosis?
It is better to have a diet that many nutrients, which are a lack of CF eat well. These are the vitamins A, D, E and K and essential fatty acids and salt. Calcium is often cited as a necessary, but the evidence is notstronger. If there is reason for the fat-soluble vitamin supplementation is an open question. If pancreatic enzyme supplements are used, then the fat-soluble vitamins in the diet should be adequately absorbed. In other words, eating is the best approach for most people with cystic fibrosis, a diet that contains a lot of foods listed below.
Essential nutrients: For most people with CF, it is important to more than others, such as the absorption from the intestine to eat is not efficient becausethe lack of pancreatic digestive enzymes. There is an increased need for essential fatty acids called Omega 6 and Omega 3 and so a diet with good sources of these fats is important. Omega-6 fatty acids are very common in modern diets, while omega-3 fatty acids are rare. For maintaining a good level of omega-3 fats in the diet are a lot oliy fish like trout, salmon, sardines, herring and sardines. A supplement that contains omega-3 such as cod liver oil may also help. The other important nutrientseat good amounts of protein, not as well absorbed in most people with CF. And "for growth in childhood have, and later for maintenance and repair of the body. Eating lots of meat, fish and some diary is the most effective way to ensure good nutrition protein. Carbohydrates are used to produce energy. However, it better not be too much alone, since it can cause spikes in blood sugar, glucose intolerance and eventually diabetes can cause. My advice is to follow a dietstressed and healthy forms of protein and fat with lots of vegetables. Eat a moderate amount of starch, like bread, pasta, rice and potatoes. Fruit and sweets are best eaten in moderation. We make sure that it is enough to be eaten in total though.
Vitamin A: This vitamin is necessary for good vision, immunity, red blood cell production and growth. It is found in high concentrations in the liver. Dairy products like cheese, milk and yogurt and eggs contain a good amountVitamin A. Dark green and yellow vegetables are also good sources of beta-carotene, which the body can be converted into vitamin A,
Vitamin D: This essential vitamin is necessary for good bone health and many other important functions in the body, such as immunity, growth and cardiovascular health. It is found in high concentrations in the liver. But the sun is the best way to get vitamin D, so that outdoor exercise offers the person with cystic fibrosis, a double benefit in the clearance of the airways and the supply ofVitamin D also.
Vitamin E: This is in good quantities in nuts, seeds and their oils, including margarine. Egg yolks and avocados also contain a good deal, and green leafy vegetables. Most of the oils from nuts and seeds, margarine contains trans fatty acids that are not good for your health. However, nut butters such as peanut butter are probably healthier than most sources of palm oil containing less trans fats than oils from sunflower, safflower and vegetable oils contain. Check the label to be sure. MyAdvice is, nuts, seeds, eggs, avocado and green leafy vegetables tossed with peanut butter to Vitamin E levels remain preserved.
Vitamin K: This vitamin can correct the bleeding, stop the uncontrolled bleeding. It also helps the formation of strong bones. It is found in green leafy vegetables. Cabbage, beets, broccoli, and parsley are all good sources.
Salt: Because people with CF sweat, salty sweat are particularly susceptible to losing a lot of salt. In contrast to thegeneral population to eat a lot of salty snacks is a good habit to develop, especially after sweating a lot during hot weather during and after exercise. Some of the healthiest ways to consume more salt is to eat more oily fish or olive. Commercial bread contains a lot of salt. Caution should be taken in children, especially under the age of one year, there is the possibility of poisoning from salt at this age.
Football: People with CF need more calcium? One reason for theircan not do is that they often suffer from kidney stones. Excess calcium in the body with calcium kidney supersaturated lead, and the production of calcium oxalate stones. Traditionally, football is as necessary for building strong bones, such as people with CF are prone been recommended for weaker bones. However, there is no evidence that I have found that the calcium balance not maintained well in people with CF. They can absorb and store properly. The reason is the development of weaker bonesto do much more with their lack of vitamin D and vitamin K. Of course, calcium is probably not necessary. Football eat foods containing dairy products, sardines should be OK if you eat large quantities. If kidney stones are already present, reduced milk is probably fine.
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